Founded in 1921, Kappa Epsilon has had an important impact on the profession of pharmacy for over 80 years through supporting personal and professional development, providing networking opportunities, promoting pharmacy as a career, and participating in various breast cancer awareness efforts. Currently, there are 37 collegiate chapters and 10 alumni chapters across the United States.

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Kappa Epsilon supports two professional endeavors on a national level: Breast Cancer Awareness and Pharmacy Career Opportunity Recruitment Project (Pharm-CORP). KE adopted breast cancer awareness as a national project in memory of Linda Rodgers, who developed breast cancer during her term as Grand Council president. During the 2005-2007 biennium, the fraternity donated nearly $15,000 to The Young Survival Coalition. As part of Pharm-CORP, Kappa Epsilon members provide presentations to local high school students to introduce a career in pharmacy. The goal of this project is to encourage students to start planning for their careers by attending the necessary classes, researching the admissions requirements for colleges of pharmacy, and learning about the various opportunities available for pharmacists.